443104-02-7
443104-02-7
Chemical Structure
CDDO-Im
Synonym(s): RTA-403; TP-235; CDDO-Imidazolide
- CAS No.: 443104-02-7
- Formula:C34H43N3O3
- Molecular Weight:541.72
IUPAC Name: (4aR,6aS,6bR,8aS,12aS,12bR,14bS)-8a-(1H-imidazole-1-carbonyl)-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-2-carbonitrile
InChIKey: ITFBYYCNYVFPKD-FMIDTUQUSA-N
SMILES: CC(C)([C@]1([H])CC[C@@]([C@@]2(CC[C@]3(CCC(C)(C[C@@]3([H])[C@]24[H])C)C(N5C=CN=C5)=O)C)6C)C(C(C#N)=C[C@]1(C)C6=CC4=O)=O
Biological Activity: CDDO-Im (RTA-403) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CDDO-Im | 99.30% | CDDO-Im (RTA-403) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ. | ||||||||||||||||||||
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References
- [1]. Place AE, et al. The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clin Cancer Res. 2003 Jul;9(7):2798-806. [Content Brief]
- [2]. Liby K, et al. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Res. 2005 Jun 1;65(11):4789-98. [Content Brief]
