444725-49-9
444725-49-9
Chemical Structure
PD-89211
- CAS. Nr.: 444725-49-9
- Formula:C19H21ClN4O
- Molecular Weight:356.85
IUPAC Name: (4-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-chlorophenyl)methanol
InChIKey: HGMLOQOHAYKVJN-UHFFFAOYSA-N
SMILES: OCC1=CC=C(N2CCN(CC3=NC4=CC=CC=C4N3)CC2)C=C1Cl
Biological Activity: PD-89211 is a selective dopamine D4 receptor antagonist with a Ki value of 3.7 nM. PD-89211 reverses Quinpirole (HY-B1752A)-induced [3H]thymidine uptake in CHOpro5 cells (IC50 = 2.1 nM). PD-89211 regulates dopamine/norepinephrine metabolism in the hippocampus and can be used for research on central nervous system disorders such as schizophrenia[1].
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PD-89211 | PD-89211 is a selective dopamine D4 receptor antagonist with a Ki value of 3.7 nM. PD-89211 reverses Quinpirole (HY-B1752A)-induced [3H]thymidine uptake in CHOpro5 cells (IC50 = 2.1 nM). PD-89211 regulates dopamine/norepinephrine metabolism in the hippocampus and can be used for research on central nervous system disorders such as schizophrenia. | |||||||||||||||||||||
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