444911-05-1
444911-05-1
Chemical Structure
16-epi-Latrunculin B
- CAS. Nr.: 444911-05-1
- Formula:C20H29NO5S
- Molecular Weight:395.51
IUPAC Name: (S)-4-((1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl)thiazolidin-2-one
InChIKey: NSHPHXHGRHSMIK-WAXGXQFOSA-N
SMILES: O=C1SC[C@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1
Biological Activity: 16-epi-latrunculin B is anticancer agent, which can inhibit the growth of HeLa cells with IC50 value of 3.9 uM[1]. 16-epi-latrunculin B has antiviral activity against HSV-1 (ED50 of 1 µg/mL)[2].
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16-epi-Latrunculin B | 16-epi-latrunculin B is anticancer agent, which can inhibit the growth of HeLa cells with IC50 value of 3.9 uM. 16-epi-latrunculin B has antiviral activity against HSV-1 (ED50 of 1 µg/mL). | |||||||||||||||||||||
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References
- [1]. Diaa T A Youssef, et al. Magnificines A and B, Antimicrobial Marine Alkaloids Featuring a Tetrahydrooxazolo[3,2-a]azepine-2,5( 3H,6H)-dione Backbone from the Red Sea Sponge Negombata magnifica. Mar Drugs. 2021 Apr 12;19(4):214. [Content Brief]
- [2]. Thomas R Hoye, et al. Toward computing relative configurations: 16-epi-latrunculin B, a new stereoisomer of the actin polymerization inhibitor latrunculin B. J Am Chem Soc. 2002 Jun 26;124(25):7405-10. [Content Brief]
