446257-23-4
Chemical Structure
YM-230888
- CAS No.: 446257-23-4
- Formula:C19H28N4OS
- Molecular Weight:360.52
IUPAC Name: (R)-N-cycloheptyl-6-((((tetrahydrofuran-2-yl)methyl)amino)methyl)thieno[2,3-d]pyrimidin-4-amine
InChIKey: SASNRPJKZVJWQW-OAHLLOKOSA-N
SMILES: C1(NC2CCCCCC2)=C3C(SC(CNC[C@H]4CCCO4)=C3)=NC=N1
Biological Activity: YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a Ki of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin (HY-13753)-induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freund's adjuvant (HY-153808)-induced arthritic pain models[1].
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YM-230888 | YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a Ki of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin (HY-13753)-induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freund's adjuvant (HY-153808)-induced arthritic pain models. | |||||||||||||||||||||
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