447458-15-3
447458-15-3
Chemical Structure
COT-01
- CAS No.: 447458-15-3
- Formula:C37H44N2O9
- Molecular Weight:660.75
InChIKey: PSXPTXQXVDVMMZ-MBCHCEKDSA-N
SMILES: O[C@]1(C(COC(CCC(N[C@@H](CC2=CNC3=C2C=CC=C3)C(OC)=O)=O)=O)=O)CC[C@@]([C@]1(C)C4)([H])[C@@]5([H])[C@]([C@](CC6)(C)C(CC5)=CC6=O)([H])C4=O
Biological Activity: COT-01 is a CRBN-dependent Cyclin D2 Molecular glue degrader with an IC50 of 2.5 μM for CRBN. COT-01 does not change CCND2 mRNA levels. COT-01 induces G0/G1 phase arrest and Apoptosis. COT-01 exhibits anticancer activity against multiple myeloma[1].
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COT-01 | COT-01 is a CRBN-dependent Cyclin D2 Molecular glue degrader with an IC50 of 2.5 μM for CRBN. COT-01 does not change CCND2 mRNA levels. COT-01 induces G0/G1 phase arrest and Apoptosis. COT-01 exhibits anticancer activity against multiple myeloma. | |||||||||||||||||||||
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