467458-02-2
467458-02-2
Chemical Structure
Idalopirdine hydrochloride
Synonym(s): Lu AE58054 hydrochloride
- CAS. Nr.: 467458-02-2
- Formula:C20H20ClF5N2O
- Molecular Weight:434.83
IUPAC Name: 2-(6-fluoro-1H-indol-3-yl)-N-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)ethan-1-amine hydrochloride
InChIKey: KXOQNPANAFXKTN-UHFFFAOYSA-N
SMILES: FC1=CC(NC=C2CCNCC3=CC(OCC(F)(F)C(F)F)=CC=C3)=C2C=C1.Cl
Biological Activity: Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders[1][2].
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Idalopirdine hydrochloride | 99.64% | Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders. | ||||||||||||||||||||
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Idalopirdine hydrochloride (Standard) | ≥98% | Idalopirdine (hydrochloride) (Standard) is the analytical standard of Idalopirdine (hydrochloride). This product is intended for research and analytical applications. Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders. | ||||||||||||||||||||
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References
- [1]. Magdalena Kotańska, et al. Idalopirdine, a selective 5-HT6 receptor antagonist, reduces food intake and body weight in a model of excessive eating. Metab Brain Dis. 2018 Jun;33(3):733-740. [Content Brief]
- [2]. Maria Amat-Foraster, et al. The 5-HT6 receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture. Neuropharmacology. 2017 Feb;113(Pt A):45-59. [Content Brief]
