469861-49-2
Chemical Structure
GW438014A
- CAS No.: 469861-49-2
- Formula:C23H23N3O4S
- Molecular Weight:437.51
IUPAC Name: N-(1-phenethyl-1H-benzo[d]imidazol-2-yl)benzamide methanesulfonate
InChIKey: AVYFZOKRFCFQLP-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1)NC2=NC3=CC=CC=C3N2CCC4=CC=CC=C4.CS(=O)(O)=O
Biological Activity: GW438014A is a selective NPY-Y5 receptor competitive antagonist capable of crossing the blood-brain barrier, with IC50 values of 197 nM and 211 nM against human receptors. GW438014A reverses PYY-mediated inhibition of Forskolin (HY-15371)-induced cAMP production, reduces NPY-induced food intake and nocturnal food intake in rodents, decreases body weight gain and fat mass in Zucker rats, and inhibits centrally mediated feeding behavior. GW438014A can be used in research related to obesity and epilepsy[1][2][3].
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GW438014A | 99.98% | GW438014A is a selective NPY-Y5 receptor competitive antagonist capable of crossing the blood-brain barrier, with IC50 values of 197 nM and 211 nM against human receptors. GW438014A reverses PYY-mediated inhibition of Forskolin (HY-15371)-induced cAMP production, reduces NPY-induced food intake and nocturnal food intake in rodents, decreases body weight gain and fat mass in Zucker rats, and inhibits centrally mediated feeding behavior. GW438014A can be used in research related to obesity and epilepsy. | ||||||||||||||||||||
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- [1]. Daniels AJ, et al. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regulatory peptides. 2002 Jun 15;106(1-3):47-54. [Content Brief]
- [2]. El Bahh B, et al. The anti‑epileptic actions of neuropeptide Y in the hippocampus are mediated by Y₂ and not Y₅ receptors. European Journal of Neuroscience. 2005;22(6):1417‑1430.
- [3]. Benmaamar R, et al. Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats. Regulatory peptides. 2005 Feb 15;125(1-3):79-83. [Content Brief]
Keywords
