50366-32-0
Chemical Structure
Flunamine
- CAS No.: 50366-32-0
- Formula:C15H15F2NO
- Molecular Weight:263.29
IUPAC Name: 2-(bis(4-fluorophenyl)methoxy)ethan-1-amine
InChIKey: BBEDRGWUDRUNQC-UHFFFAOYSA-N
SMILES: FC1=CC=C(C=C1)C(OCCN)C2=CC=C(F)C=C2
Biological Activity: Flunamine is a broad-spectrum monoamine transporter inhibitor that inhibits the uptake of dopamine (DA), 5-hydroxytryptamine (5-HT), and noradrenaline (NA) in rat brain synaptosomes. The IC50 values of Flunamine for DA and 5-HT uptake in rat striatal synaptosomes are 0.26 μM and 0.17 μM, respectively, and the IC50 values for 5-HT and NA uptake in hypothalamic synaptosomes are 0.24 μM and 0.092 μM, respectively. Flunamine acts through broad-spectrum inhibition of dopaminergic, serotonergic, and noradrenergic monoamine reuptake and is used in research related to depression and Parkinson's disease[1][2][3].
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Flunamine | Flunamine is a broad-spectrum monoamine transporter inhibitor that inhibits the uptake of dopamine (DA), 5-hydroxytryptamine (5-HT), and noradrenaline (NA) in rat brain synaptosomes. The IC50 values of Flunamine for DA and 5-HT uptake in rat striatal synaptosomes are 0.26 μM and 0.17 μM, respectively, and the IC50 values for 5-HT and NA uptake in hypothalamic synaptosomes are 0.24 μM and 0.092 μM, respectively. Flunamine acts through broad-spectrum inhibition of dopaminergic, serotonergic, and noradrenergic monoamine reuptake and is used in research related to depression and Parkinson's disease. | |||||||||||||||||||||
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References
- [1]. Gootjes J. Aminoalkylethers. US, US4003932A. 1977-01-18.
- [2]. Van der Zee P, et al. A comparison of the inhibitory effects of aromatic substituted benzhydryl ethers on the uptake of catecholamines and serotonin into synaptosomal preparations of the rat brain. Neuropharmacology. 1978;17(7):483-490.
- [3]. Mueller A, et al. Methods and compounds for treating depression and other disorders. WO, WO0002551A2. 2000-01-20.
