Flunamine
Flunamine is a broad-spectrum monoamine transporter inhibitor that inhibits the uptake of dopamine (DA), 5-hydroxytryptamine (5-HT), and noradrenaline (NA) in rat brain synaptosomes. The IC50 values of Flunamine for DA and 5-HT uptake in rat striatal synaptosomes are 0.26 μM and 0.17 μM, respectively, and the IC50 values for 5-HT and NA uptake in hypothalamic synaptosomes are 0.24 μM and 0.092 μM, respectively. Flunamine acts through broad-spectrum inhibition of dopaminergic, serotonergic, and noradrenergic monoamine reuptake and is used in research related to depression and Parkinson's disease.
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- No. CAS: 50366-32-0
- Fòrmula: C15H15F2NO
- Peso molecular:263.29
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Actividad biológica
Descripciòn
IC50 & Target
[2]|
DAT 0.26 μM (IC50) |
SERT 0.17 μM (IC50) |
SERT 0.24 μM (IC50) |
NET 0.092 μM (IC50) |
In Vitro
Flunamine (preincubation for 10 min; uptake incubation for 5 min) inhibits the uptake of 5-HT and NA in rat hypothalamic synaptosomes, with IC50 values of 0.24 μM and 0.092 μM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 50366-32-0
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Peso molecular 263.29
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Fòrmula C15H15F2NO
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SMILES
FC1=CC=C(C=C1)C(OCCN)C2=CC=C(F)C=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Flunamine Related Classifications
HY-W367959 Related Classifications
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