50650-76-5
50650-76-5
Chemical Structure
Piroctone
- CAS No.: 50650-76-5
- Formula:C14H23NO2
- Molecular Weight:237.34
InChIKey: OIQJEQLSYJSNDS-UHFFFAOYSA-N
SMILES: O=C1C=C(C)C=C(CC(CC(C)(C)C)C)N1O
Biological Activity: Piroctone is a potent hydroxypyridone antimicrobial agent that shows remarkable activity against fungi including Candida species. Piroctone inhibits hyphal induction of Candida albicans. Piroctone can efficiently chelate intracellular iron to induce relevant cytotoxicity in neuroblastoma cells. Piroctone can be used for antimicrobial and neuroblastoma research[1][2].
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Piroctone | Piroctone is a potent hydroxypyridone antimicrobial agent that shows remarkable activity against fungi including Candida species. Piroctone inhibits hyphal induction of Candida albicans. Piroctone can efficiently chelate intracellular iron to induce relevant cytotoxicity in neuroblastoma cells. Piroctone can be used for antimicrobial and neuroblastoma research. | |||||||||||||||||||||
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References
- [1]. Sigle HC, et al. In vitro investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans. Mycoses. 2006 May;49(3):159-68. [Content Brief]
- [2]. Sidarovich V, et al. Translational downregulation of HSP90 expression by iron chelators in neuroblastoma cells. Mol Pharmacol. 2015;87(3):513-24. [Content Brief]
Keywords
