509-80-8
Chemical Structure
Mitraphylline
- CAS. Nr.: 509-80-8
- Formula:C21H24N2O4
- Molecular Weight:368.43
IUPAC Name: methyl (1'S,3R,4a'S,5a'S,10a'R)-1'-methyl-2-oxo-4a',5',5a',7',8',10a'-hexahydro-1'H,10'H-spiro[indoline-3,6'-pyrano[3,4-f]indolizine]-4'-carboxylate
InChIKey: JMIAZDVHNCCPDM-DAFCLMLCSA-N
SMILES: O=C1NC2=C([C@@]13CCN4C[C@@]5([C@@H](OC=C([C@]5(C[C@]43[H])[H])C(OC)=O)C)[H])C=CC=C2
Biological Activity: Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo[1][2][3].
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Mitraphylline | 99.61% | Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo. | ||||||||||||||||||||
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Mitraphylline (Standard) | ≥98% | Mitraphylline (Standard) is the analytical standard of Mitraphylline. This product is intended for research and analytical applications. Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo. | ||||||||||||||||||||
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- [1]. Montserrat-de la Paz S, et al. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine. 2016 Feb 15;23(2):141-8. [Content Brief]
- [2]. Rojas-Duran, R., et al., (2012). Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of ethnopharmacology, 143(3), 801–804. [Content Brief]
- [3]. García Prado, E., et al., (2007). Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine : international journal of phytotherapy and phytopharmacology, 14(4), 280–284. [Content Brief]
