51103-57-2
Chemical Structure
Aphidicolin 17-acetate
Synonym(s): Aphidicolin 17-monoacetate
- CAS. Nr.: 51103-57-2
- Formula:C22H36O5
- Molecular Weight:380.52
IUPAC Name: ((3R,4R,4aR,6aS,8R,9R,11aS,11bS)-3,9-dihydroxy-4-(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalen-9-yl)methyl acetate
InChIKey: GAPINCSXTLCIPV-BORIEPGUSA-N
SMILES: O[C@]1(COC(C)=O)CC[C@@]23[C@@]([C@@]4([H])CC[C@@]2([H])C[C@@H]1C3)(C)CC[C@@H](O)[C@@]4(C)CO
Biological Activity: Aphidicolin 17-acetate is a selective eukaryotic DNA polymerase α inhibitor. Aphidicolin 17-acetate does not inhibit DNA polymerase β and γ. Aphidicolin 17-acetate markedly inhibits the in vivo DNA synthesis of sea urchin embryos and HeLa cells but not RNA and protein syntheses[1].
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Aphidicolin 17-acetate | Aphidicolin 17-acetate is a selective eukaryotic DNA polymerase α inhibitor. Aphidicolin 17-acetate does not inhibit DNA polymerase β and γ. Aphidicolin 17-acetate markedly inhibits the in vivo DNA synthesis of sea urchin embryos and HeLa cells but not RNA and protein syntheses. | |||||||||||||||||||||
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