51798-45-9
Chemical Structure
Elastatinal
- CAS No.: 51798-45-9
- Formula:C21H36N8O7
- Molecular Weight:512.56
IUPAC Name: (((S)-2-(((S)-5-amino-1,5-dioxo-1-(((S)-1-oxopropan-2-yl)amino)pentan-2-yl)amino)-1-((S)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-oxoethyl)carbamoyl)-L-leucine
InChIKey: IJWCGVPEDDQUDE-YGJAXBLXSA-N
SMILES: O=C[C@H](C)NC([C@H](CCC(N)=O)NC([C@H]([C@@]1([H])NC(N)=NCC1)NC(N[C@H](C(O)=O)CC(C)C)=O)=O)=O
Biological Activity: Elastatinal is a potent and competitive inhibitor of elastase, with a Ki of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Elastatinal | 99.9% | Elastatinal is a potent and competitive inhibitor of elastase, with a Ki of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease. | ||||||||||||||||||||
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Elastatinal (Standard) | ≥98% | Phenethyl acetate (Standard) is the analytical standard of Phenethyl acetate. This product is intended for research and analytical applications. Phenethyl acetate (Phenethyl alcohol) is a natural product. | ||||||||||||||||||||
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References
- [1]. Umezawa H. Structures and activities of protease inhibitors of microbial origin. Methods Enzymol. 1976;45:678-95. [Content Brief]
- [2]. Feinstein G, et, al. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim Biophys Acta. 1976 May 13;429(3):925-32. [Content Brief]
- [3]. Sugisaki R, et, al. Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin. Bone. 2020 Mar;132:115216. [Content Brief]
- [4]. Vidhya R, et, al. Anti-inflammatory effects of troxerutin are mediated through elastase inhibition. Immunopharmacol Immunotoxicol. 2020 Oct;42(5):423-435. [Content Brief]
