526-02-3
526-02-3
Chemical Structure
Actiphenol
- CAS No.: 526-02-3
- Formula:C15H17NO4
- Molecular Weight:275.30
IUPAC Name: 4-(2-(2-hydroxy-3,5-dimethylphenyl)-2-oxoethyl)piperidine-2,6-dione
InChIKey: YTLMIHBTPWTPEV-UHFFFAOYSA-N
SMILES: O=C1NC(CC(CC(C2=C(O)C(C)=CC(C)=C2)=O)C1)=O
Biological Activity: Actiphenol is an antibiotic against coxsackievirus B3 and influenza A virus (IC50s = 14.37 and 34.4 µg/mL, respectively). Actiphenol is also an aromatic ketone that exhibits weak eukaryotic translation inhibiton activity, which is found in Streptomyces species. Actiphenol can be used as a key intermediate to synthesize Cycloheximide (HY-12320)[1][2].
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Actiphenol | Actiphenol is an antibiotic against coxsackievirus B3 and influenza A virus (IC50s = 14.37 and 34.4 µg/mL, respectively). Actiphenol is also an aromatic ketone that exhibits weak eukaryotic translation inhibiton activity, which is found in Streptomyces species. Actiphenol can be used as a key intermediate to synthesize Cycloheximide (HY-12320). | |||||||||||||||||||||
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References
- [1]. Ji XY, et al. Synthesis and antiviral activities of synthetic glutarimide derivatives. Chem Pharm Bull (Tokyo). 2010 Nov;58(11):1436-41. [Content Brief]
- [2]. Yin M, et al. Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. Org Lett. 2014 Jun 6;16(11):3072-5. [Content Brief]
