52688-60-5
Chemical Structure
MAO-B-IN-54
- CAS No.: 52688-60-5
- Formula:C14H17N3
- Molecular Weight:227.31
IUPAC Name: N1,N1-dimethyl-N4-(pyridin-2-ylmethyl)benzene-1,4-diamine
InChIKey: RIKLBFYMQFBFJF-UHFFFAOYSA-N
SMILES: N=1C=CC=CC1CNC2=CC=C(C=C2)N(C)C
Biological Activity: MAO-B-IN-54 is a selective, reversible and competitiv monoamine oxidase B (MAOB) inhibitor with a human IC50 of 0.052 μM and a Ki of 0.028 μM. MAO-B-IN-54 shows weak activity MAOA. MAO-B-IN-54 occupies both the entrance and substrate cavity of MAOB, forming hydrophobic and hydrogen bonding interactions. MAO-B-IN-54 inhibits Aβ aggregation and ROS production. MAO-B-IN-54 can be used for the research of Alzheimer’s disease[1].
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MAO-B-IN-54 | MAO-B-IN-54 is a selective, reversible and competitiv monoamine oxidase B (MAOB) inhibitor with a human IC50 of 0.052 μM and a Ki of 0.028 μM. MAO-B-IN-54 shows weak activity MAOA. MAO-B-IN-54 occupies both the entrance and substrate cavity of MAOB, forming hydrophobic and hydrogen bonding interactions. MAO-B-IN-54 inhibits Aβ aggregation and ROS production. MAO-B-IN-54 can be used for the research of Alzheimer’s disease. | |||||||||||||||||||||
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Keywords
