MAO-B-IN-54
MAO-B-IN-54 is a selective, reversible and competitiv monoamine oxidase B (MAOB) inhibitor with a human IC50 of 0.052 μM and a Ki of 0.028 μM. MAO-B-IN-54 shows weak activity MAOA. MAO-B-IN-54 occupies both the entrance and substrate cavity of MAOB, forming hydrophobic and hydrogen bonding interactions. MAO-B-IN-54 inhibits Aβ aggregation and ROS production. MAO-B-IN-54 can be used for the research of Alzheimer’s disease.
For research use only. We do not sell to patients.
- CAS No.: 52688-60-5
- Formula: C14H17N3
- Molecular Weight:227.31
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
hMAO-B 0.052 μM (IC50) |
hMAO-A 0.67 μM (IC50) |
hMAO-B 0.028 μM (Ki) |
hMAO-A 0.19 μM (Ki) |
MAO-B-IN-54 (Compound L2-b) (0-60 min) potently and competitively inhibits recombinant human MAO-B and MAO-A in a reversible manner, with IC50 values of 0.052 annd 0.67 μM and Ki values of 0.028 and 0.19 μM, and binds to both the entrance and substrate cavities of the enzyme[1].
MAO-B-IN-54 modulates metal-associated amyloid-beta (Aβ) species, attenuates metal-triggered Aβ aggregation, neurotoxicity, and reactive oxygen species (ROS) generation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 52688-60-5
-
Molecular Weight 227.31
-
Formula C14H17N3
-
SMILES
N=1C=CC=CC1CNC2=CC=C(C=C2)N(C)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz