2. Neuronal Signaling NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Monoamine Oxidase Amyloid-β Reactive Oxygen Species (ROS)
  4. MAO-B-IN-54

MAO-B-IN-54 is a selective, reversible and competitiv monoamine oxidase B (MAOB) inhibitor with a human IC50 of 0.052 μM and a Ki of 0.028 μM. MAO-B-IN-54 shows weak activity MAOA. MAO-B-IN-54 occupies both the entrance and substrate cavity of MAOB, forming hydrophobic and hydrogen bonding interactions. MAO-B-IN-54 inhibits Aβ aggregation and ROS production. MAO-B-IN-54 can be used for the research of Alzheimer’s disease.

For research use only. We do not sell to patients.

MAO-B-IN-54

MAO-B-IN-54 Chemical Structure

CAS No. : 52688-60-5

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MAO-B-IN-54 Related Antibodies

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MAO-A MAO-B

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Description

MAO-B-IN-54 is a selective, reversible and competitiv monoamine oxidase B (MAOB) inhibitor with a human IC50 of 0.052 μM and a Ki of 0.028 μM. MAO-B-IN-54 shows weak activity MAOA. MAO-B-IN-54 occupies both the entrance and substrate cavity of MAOB, forming hydrophobic and hydrogen bonding interactions. MAO-B-IN-54 inhibits Aβ aggregation and ROS production. MAO-B-IN-54 can be used for the research of Alzheimer’s disease[1].

IC50 & Target[1]

hMAO-B

0.052 μM (IC50)

hMAO-A

0.67 μM (IC50)

hMAO-B

0.028 μM (Ki)

hMAO-A

0.19 μM (Ki)

In Vitro

MAO-B-IN-54 (Compound L2-b) (0-60 min) potently and competitively inhibits recombinant human MAO-B and MAO-A in a reversible manner, with IC50 values of 0.052 annd 0.67 μM and Ki values of 0.028 and 0.19 μM, and binds to both the entrance and substrate cavities of the enzyme[1].
MAO-B-IN-54 modulates metal-associated amyloid-beta (Aβ) species, attenuates metal-triggered Aβ aggregation, neurotoxicity, and reactive oxygen species (ROS) generation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-54 Related Antibodies
Molecular Weight

227.31

Formula

C14H17N3
CAS No.
SMILES

N=1C=CC=CC1CNC2=CC=C(C=C2)N(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO-B-IN-54 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-5452688-60-5Monoamine OxidaseAmyloid-βReactive Oxygen Species (ROS)MAOβ-amyloid peptideAβAbetaMAOBMAOAreactive oxygen speciesAlzheimer’s diseasemonoamine oxidase BParkinson’s diseaseamyloid-betaROSInhibitorinhibitorinhibit

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