53882-13-6
Chemical Structure
Diethyl-Lodoxamide
- CAS No.: 53882-13-6
- Formula:C15H14ClN3O6
- Molecular Weight:367.74
InChIKey: BNTAPIYHWPPFBW-UHFFFAOYSA-N
SMILES: N#CC1=CC(NC(C(OCC)=O)=O)=C(Cl)C(NC(C(OCC)=O)=O)=C1
Biological Activity: Diethyl-Lodoxamide is a highly potent GPR35 agonist with potential to inhibit inflammatory bowel disease. Diethyl-Lodoxamide activates GPR35 in humans, mice and rats, showing similar EC50 values. Diethyl-Lodoxamide can alleviate the clinical symptoms of DSS-induced inflammatory bowel disease in mouse models, and the effect is better than the traditional drug 5-ASA. The pharmaceutical properties of Diethyl-Lodoxamide have been optimized to better meet the requirements of drug design[1].
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Diethyl-Lodoxamide | Diethyl-Lodoxamide is a highly potent GPR35 agonist with potential to inhibit inflammatory bowel disease. Diethyl-Lodoxamide activates GPR35 in humans, mice and rats, showing similar EC50 values. Diethyl-Lodoxamide can alleviate the clinical symptoms of DSS-induced inflammatory bowel disease in mouse models, and the effect is better than the traditional drug 5-ASA. The pharmaceutical properties of Diethyl-Lodoxamide have been optimized to better meet the requirements of drug design. | |||||||||||||||||||||
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Keywords
