539-35-5
539-35-5
Chemical Structure
Actithiazic acid
Synonym(s): Mycobacidin; Cinnamonin; Acidomycin
- CAS No.: 539-35-5
- Formula:C9H15NO3S
- Molecular Weight:217.29
InChIKey: CSOJYIADHHNGRM-UHFFFAOYSA-N
SMILES: O=C(CCCCCC1SCC(N1)=O)O
Biological Activity: Actithiazic acid is a thiazolidinone antibiotic that targets biotin synthase. Actithiazic acid interferes with essential bacterial metabolism by inhibiting the final step of biotin synthesis (conversion of desthiobiotin to biotin, IC50 = 0.45 μM). Actithiazic acid can be used in studies related to mycobacterial infections[1][2].
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Actithiazic acid | Actithiazic acid is a thiazolidinone antibiotic that targets biotin synthase. Actithiazic acid interferes with essential bacterial metabolism by inhibiting the final step of biotin synthesis (conversion of desthiobiotin to biotin, IC50 = 0.45 μM). Actithiazic acid can be used in studies related to mycobacterial infections. | |||||||||||||||||||||
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References
- [1]. Eisenberg MA, et al. Mode of action of the biotin antimetabolites actithiazic acid and alpha-methyldethiobiotin. Antimicrob Agents Chemother. 1982;21(1):5-10. [Content Brief]
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[2]. Nadkarni SR, et al. In vitro synergy of actithiazic acid, an antimetabolite of biotin, combined with cephalexin. The Journal of Antibiotics. 1983;36(11):1567-8.
