54081-48-0
Chemical Structure
Isoastilbin
- No. CAS: 54081-48-0
- Formula:C21H22O11
- Molecular Weight:450.39
IUPAC Name: (2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)chroman-4-one
InChIKey: ZROGCCBNZBKLEL-OOHAXVOVSA-N
SMILES: O[C@H]([C@@H]([C@@H](O)[C@H](C)O1)O)[C@]1([H])O[C@H]2[C@@H](C3=CC(O)=C(O)C=C3)OC4=CC(O)=CC(O)=C4C2=O
Biological Activity: Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research[1][21][3].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Isoastilbin | 99.80% | Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research. | ||||||||||||||||||||
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Similarity Score 1.00
HY-N0509RAstilbin (Standard) -
Similarity Score 1.00
HY-N5115Neosmitilbin -
Similarity Score 1.00
HY-N5116Neoisoastilbin -
Similarity Score 0.90
HY-N0961(2S,3S)-(-)-Glucodistylin -
Similarity Score 0.90
HY-N13500(2R,3R)-Glucodistylin -
Similarity Score 0.89
HY-N10701AChE/BChE-IN-11 -
Similarity Score 0.88
HY-N175233,5,7,3,5-Pentahydroxy-2R,3R-flavanonol 3-O-α-L-rhamnopyranoside -
Similarity Score 0.87
HY-N1172Taxifolin 3-O-bata-xylopyranoside -
Similarity Score 0.87
HY-N17874(2R,3R)-Taxifolin-3-O-α-L-arabinopyranoside -
Explore the MedChemAI to find more analogs
References
- [1]. Hong Yu, et al. Protective Roles of Isoastilbin Against Alz heimer's Disease via Nrf2-mediated Antioxidation and anti‑apoptosis. Int J Mol Med. 2019 Mar;43(3):1406-1416. [Content Brief]
- [3]. Batubara, Irmanida, et al. Anti-acne and Tyrosinase Inhibition Properties of Taxifolin and Some Flavanonol Rhamnosides from Kempas. Wood Research Journal ,2010, 1(1):45-9.
