54340-62-4
54340-62-4
Chemical Structure
Bufuralol
Synonym(s): Ro 3-4787
- CAS No.: 54340-62-4
- Formula:C16H23NO2
- Molecular Weight:261.36
IUPAC Name: 2-(tert-butylamino)-1-(7-ethylbenzofuran-2-yl)ethan-1-ol
InChIKey: SSEBTPPFLLCUMN-UHFFFAOYSA-N
SMILES: CCC1=CC=CC2=C1OC(C(O)CNC(C)(C)C)=C2
Biological Activity: Bufuralol (Ro 3-4787) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2][3][4].
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Bufuralol | 99.25% | Bufuralol (Ro 3-4787) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate. | ||||||||||||||||||||
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Bufuralol (Standard) | ≥98% | Bufuralol (Standard) is the analytical standard of Bufuralol (HY-105124). This product is intended for research and analytical applications. Bufuralol (Ro 3-4787) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate. | ||||||||||||||||||||
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References
- [1]. T H Pringle, et al. Pharmacodynamic and pharmacokinetic studies on bufuralol in man. Br J Clin Pharmacol. 1986 Nov;22(5):527-34. [Content Brief]
- [2]. Jie Cai, et al. Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro. Basic Clin Pharmacol Toxicol. 2016 Mar;118(3):190-9. [Content Brief]
- [3]. Sarah M Glass, et al. CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712. Drug Metab Dispos. 2018 Aug;46(8):1106-1117. [Content Brief]
- [4]. T Prueksaritanont, et al. (+)-bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liver. Biochem Pharmacol. 1995 Oct 26;50(9):1521-5. [Content Brief]
Keywords
