544-05-8
544-05-8
Chemical Structure
Arcaine
Synonym(s): ARC
- CAS No.: 544-05-8
- Formula:C6H16N6
- Molecular Weight:172.24
IUPAC Name: 1,1'-(butane-1,4-diyl)diguanidine
InChIKey: HGMDNMBBCKDWTQ-UHFFFAOYSA-N
SMILES: N=C(N)NCCCCNC(=N)N
Biological Activity: Arcaine (ARC) is a competitive NMDA receptor polyamine site antagonist and Agmatinase inhibitor. Arcaine inhibits NOS. Arcaine shows anticonvulsant activity and induces state-dependent inhibitory avoidance memory impairment involving the opioid system. Arcaine can be used in research on alcohol use disorder[1][2][3][4][5][6][7][8].
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Arcaine | Arcaine (ARC) is a competitive NMDA receptor polyamine site antagonist and Agmatinase inhibitor. Arcaine inhibits NOS. Arcaine shows anticonvulsant activity and induces state-dependent inhibitory avoidance memory impairment involving the opioid system. Arcaine can be used in research on alcohol use disorder. | |||||||||||||||||||||
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References
- [1]. Araneda RC, et al. Spermine and arcaine block and permeate N-methyl-D-aspartate receptor channels. Biophysical journal. 1999 Jun;76(6):2899-911.
- [2]. Yourick DL, et al. Ifenprodil and arcaine alter amygdala-kindling development. European journal of pharmacology. 1999 Apr 29;371(2-3):147-52.
- [3]. Doyle KM, et al. Investigation of the actions and antagonist activity of some polyamine analogues in vivo. British journal of pharmacology. 1998 May;124(2):386-90.
- [4]. Ceretta AP, et al. Arcaine and MK-801 make recall state-dependent in rats. Psychopharmacology. 2008 Dec;201(3):405-11.
- [5]. Mariani RK, et al. Effect of naloxone and morphine on arcaine-induced state-dependent memory in rats. Psychopharmacology. 2011 Jun;215(3):483-91.
- [6]. Camera K, et al. Systemic administration of polyaminergic agents modulate fear conditioning in rats. Psychopharmacology. 2007 Jul;192(4):457-64.
- [7]. Donevan SD, et al. Arcaine blocks N-methyl-D-aspartate receptor responses by an open channel mechanism: whole-cell and single-channel recording studies in cultured hippocampal neurons. Molecular pharmacology. 1992 Apr 1;41(4):727-35.
- [8]. Kotagale N, et al. Agmatine prevents development of tolerance to anti-nociceptive effect of ethanol in mice. Alcohol (Fayetteville, N.Y.). 2022 Jun;101:1-8.
