549494-39-5
Chemical Structure
AZD4619
- CAS No.: 549494-39-5
- Formula:C26H28O7S2
- Molecular Weight:516.63
IUPAC Name: (S)-2-((4-hydroxyphenethyl)thio)-3-(4-(2-(4-(sulfooxy)phenoxy)ethyl)phenyl)propanoic acid
InChIKey: YFAQRIHKVFJDJQ-DEOSSOPVSA-N
SMILES: OC(C=C1)=CC=C1CCS[C@H](C(O)=O)CC2=CC=C(C=C2)CCOC3=CC=C(C=C3)OS(C)(=O)=O
Biological Activity: AZD4619 is an orally active, selective peroxisome proliferator-activated receptor α (PPARα) agonist. AZD4619 increases alanine aminotransferase 1 (ALT1) protein expression in a dose-dependent manner in human, but not in rat primary hepatocytes. AZD4619 is a lipid-lowering drug[1][2].
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AZD4619 | AZD4619 is an orally active, selective peroxisome proliferator-activated receptor α (PPARα) agonist. AZD4619 increases alanine aminotransferase 1 (ALT1) protein expression in a dose-dependent manner in human, but not in rat primary hepatocytes. AZD4619 is a lipid-lowering drug. | |||||||||||||||||||||
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- [1]. Petra Thulin, et al. PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes. Toxicol Appl Pharmacol. 2008 Aug 15;231(1):1-9. [Content Brief]
- [2]. Petra Thulin, et al. The peroxisome proliferator-activated receptor α agonist, AZD4619, induces alanine aminotransferase-1 gene and protein expression in human, but not in rat hepatocytes: Correlation with serum ALT levels. Int J Mol Med. 2016 Sep;38(3):961-8. [Content Brief]
Keywords
