55836-69-6
Chemical Structure
3-Ethoxybenzamide
- CAS No.: 55836-69-6
- Formula:C9H11NO2
- Molecular Weight:165.19
IUPAC Name: 3-ethoxybenzamide
InChIKey: NDOYNKFWOCOOIR-UHFFFAOYSA-N
SMILES: O=C(N)C=1C=CC=C(OCC)C1
Biological Activity: 3-Ethoxybenzamide is an alkoxybenzamide compound with antibacterial activity and a FtsZ inhibitor that can cross the blood-brain barrier. 3-Ethoxybenzamide distributes widely and rapidly in vivo, rapidly reaches equilibrium between various tissues and blood, and is linearly taken up by hepatocytes. 3-Ethoxybenzamide is completely dependent on hepatic microsomal oxidation for clearance, with salicylamide as its major metabolite. 3-Ethoxybenzamide can be used for the study of bacterial infections[1][2].
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3-Ethoxybenzamide | 3-Ethoxybenzamide is an alkoxybenzamide compound with antibacterial activity and a FtsZ inhibitor that can cross the blood-brain barrier. 3-Ethoxybenzamide distributes widely and rapidly in vivo, rapidly reaches equilibrium between various tissues and blood, and is linearly taken up by hepatocytes. 3-Ethoxybenzamide is completely dependent on hepatic microsomal oxidation for clearance, with salicylamide as its major metabolite. 3-Ethoxybenzamide can be used for the study of bacterial infections. | |||||||||||||||||||||
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- [1]. Lin JH, et al. Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data. J Pharmacokinet Biopharm. 1982;10(6):649-661. [Content Brief]
- [2]. Czaplewski LG, et al. Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ. Bioorg Med Chem Lett. 2009;19(2):524-527. [Content Brief]
Keywords
