Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

  • Bioorg Med Chem Lett. 2009 Jan 15;19(2):524-7. doi: 10.1016/j.bmcl.2008.11.021.
Lloyd G Czaplewski  1 ,  Ian Collins ,  E Andrew Boyd ,  David Brown ,  Stephen P East ,  Mihaly Gardiner ,  Rowena Fletcher ,  David J Haydon ,  Vincent Henstock ,  Peter Ingram ,  Clare Jones ,  Caterina Noula ,  Leanne Kennison ,  Chris Rockley ,  Valerie Rose ,  Helena B Thomaides-Brears ,  Rebecca Ure ,  Mark Whittaker ,  Neil R Stokes
Affiliations
  • 1. Prolysis Ltd, Begbroke Science Park, Sandy Lane, Yarnton, Oxfordshire OX5 1PF, UK.
PMID: 19064318 DOI: 10.1016/j.bmcl.2008.11.021
Abstract

3-Methoxybenzamide is a weak inhibitor of the essential Bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.

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