55837-25-7
55837-25-7
Chemical Structure
Buflomedil
- CAS No.: 55837-25-7
- Formula:C17H25NO4
- Molecular Weight:307.38
IUPAC Name: 4-(pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one
InChIKey: OWYLAEYXIQKAOL-UHFFFAOYSA-N
SMILES: O=C(C1=C(OC)C=C(OC)C=C1OC)CCCN2CCCC2
Biological Activity: Buflomedil, a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with Kis of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil can be used for the study of peripheral circulatory disorders[1][2].
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Buflomedil | Buflomedil, a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with Kis of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil can be used for the study of peripheral circulatory disorders. | |||||||||||||||||||||
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References
- [1]. de Backer TL, et al. Buflomedil for intermittent claudication. Cochrane Database Syst Rev. 2013 Mar 28;2013(3):CD000988. [Content Brief]
- [2]. Limbs International Medicinal Buflomedil (LIMB) Study Group; Leizorovicz A, Becker F. Oral buflomedil in the prevention of cardiovascular events in patients with peripheral arterial obstructive disease: a randomized, placebo-controlled, 4-year study. Circulation. 2008 Feb 12;117(6):816-22. [Content Brief]
