55905-53-8
55905-53-8
Chemical Structure
Clebopride
- CAS No.: 55905-53-8
- Formula:C20H24ClN3O2
- Molecular Weight:373.88
IUPAC Name: 4-amino-N-(1-benzylpiperidin-4-yl)-5-chloro-2-methoxybenzamide
InChIKey: BVPWJMCABCPUQY-UHFFFAOYSA-N
SMILES: O=C(NC1CCN(CC2=CC=CC=C2)CC1)C3=CC(Cl)=C(N)C=C3OC
Biological Activity: Clebopride is an orally active dopamine Receptor antagonist. Clebopride acts on dopamine D2 receptors and has antiemetic and prokinetic effects. Clebopride can be used in the study of functional gastrointestinal disorders[1][2][3][4].
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Clebopride | Clebopride is an orally active dopamine Receptor antagonist. Clebopride acts on dopamine D2 receptors and has antiemetic and prokinetic effects. Clebopride can be used in the study of functional gastrointestinal disorders. | |||||||||||||||||||||
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References
- [1]. Reis-Carneiro D, et al. Clebopride-Associated Movement Disorders. Mov Disord Clin Pract. 2023 Sep 6;10(10):1562-1563. [Content Brief]
- [2]. Elliott PN, et al. Substituted benzamides as cerebral dopamine antagonists in rodents. Neuropharmacology. 1977 May;16(5):333-42. [Content Brief]
- [3]. Takeda K, et al. Clebopride enhances contractility of the guinea pig stomach by blocking peripheral D2 dopamine receptor and alpha-2 adrenoceptor. J Pharmacol Exp Ther. 1991 May;257(2):806-11. [Content Brief]
- [4]. Segura J, et al. The pharmacokinetics of a new benzamide drug clebopride, in the rat and the dog. J Pharm Pharmacol. 1981 Apr;33(4):214-8. [Content Brief]
Keywords
