56883-39-7
Chemical Structure
2-Azido-2-deoxy-D-glucose, 98%
Synonym(s): 2-ADG, 98%
- CAS No.: 56883-39-7
- Formula:C6H11N3O5
- Molecular Weight:205.17
IUPAC Name: (2R,3R,4S,5R)-2-azido-3,4,5,6-tetrahydroxyhexanal
InChIKey: MUIFUJRYFJTPGL-SLPGGIOYSA-N
SMILES: OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](C=O)N=[N+]=[N-]
Biological Activity: 2-Azido-2-deoxy-D-glucose, 98% (2-ADG, 98%) is a substrate of O-GlcNAc transferase (OGT). 2-Azido-2-deoxy-D-glucose, 98% can be transferred from UDP-GlcAz to proteins in vitro via OGT mediation. When delivered as AcGlcAz, 2-Azido-2-deoxy-D-glucose, 98% enables the labeling and investigation of O-GlcNAc-modified nuclear and cytoplasmic proteins in cells. 2-Azido-2-deoxy-D-glucose, 98% undergoes strain-promoted [3+2] azide-alkyne cycloaddition (SPAAC) with technetium-99m-labeled dibenzocyclooctyne derivatives in vivo. 2-Azido-2-deoxy-D-glucose, 98% can be used in sarcoma-related research[1][2].
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2-Azido-2-deoxy-D-glucose, 98% | 98.0% | 2-Azido-2-deoxy-D-glucose, 98% (2-ADG, 98%) is a substrate of O-GlcNAc transferase (OGT). 2-Azido-2-deoxy-D-glucose, 98% can be transferred from UDP-GlcAz to proteins in vitro via OGT mediation. When delivered as AcGlcAz, 2-Azido-2-deoxy-D-glucose, 98% enables the labeling and investigation of O-GlcNAc-modified nuclear and cytoplasmic proteins in cells. 2-Azido-2-deoxy-D-glucose, 98% undergoes strain-promoted [3+2] azide-alkyne cycloaddition (SPAAC) with technetium-99m-labeled dibenzocyclooctyne derivatives in vivo. 2-Azido-2-deoxy-D-glucose, 98% can be used in sarcoma-related research. | ||||||||||||||||||||
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References
- [1]. Shen DL, et al. Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose. ACS Chem Biol. 2017;12(1):206-213. [Content Brief]
- [2]. Ding J, et al. A pre-targeting strategy for imaging glucose metabolism using technetium-99m labelled dibenzocyclooctyne derivative. Bioorg Med Chem Lett. 2019;29(14):1791-1798. [Content Brief]
