56961-10-5
56961-10-5
Chemical Structure
SARS-CoV-2-IN-13
- CAS No.: 56961-10-5
- Formula:C13H8Cl2N2O4
- Molecular Weight:327.12
IUPAC Name: 5-chloro-N-(3-chloro-4-nitrophenyl)-2-hydroxybenzamide
InChIKey: FKLGWJUBUPDJJI-UHFFFAOYSA-N
SMILES: O=C(C1=C(C=CC(Cl)=C1)O)NC2=CC(Cl)=C(C=C2)[N+]([O-])=O
Biological Activity: SARS-CoV-2-IN-13 (compound 5) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.057 μM. SARS-CoV-2-IN-13 is a niclosamide analogue. SARS-CoV-2-IN-13 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].
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SARS-CoV-2-IN-13 | 98.53% | SARS-CoV-2-IN-13 (compound 5) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.057 μM. SARS-CoV-2-IN-13 is a niclosamide analogue. SARS-CoV-2-IN-13 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally. | ||||||||||||||||||||
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