2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2-IN-13

SARS-CoV-2-IN-13 (compound 5) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.057 μM. SARS-CoV-2-IN-13 is a niclosamide analogue. SARS-CoV-2-IN-13 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally.

For research use only. We do not sell to patients.

SARS-CoV-2-IN-13 Chemical Structure

SARS-CoV-2-IN-13 Chemical Structure

CAS No. : 56961-10-5

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

SARS-CoV-2-IN-13 Related Antibodies

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Description

SARS-CoV-2-IN-13 (compound 5) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.057 μM. SARS-CoV-2-IN-13 is a niclosamide analogue. SARS-CoV-2-IN-13 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].

Molecular Weight

327.12

Formula

C13H8Cl2N2O4
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(C1=C(C=CC(Cl)=C1)O)NC2=CC(Cl)=C(C=C2)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (382.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0570 mL 15.2849 mL 30.5698 mL
5 mM 0.6114 mL 3.0570 mL 6.1140 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0570 mL 15.2849 mL 30.5698 mL 76.4246 mL
5 mM 0.6114 mL 3.0570 mL 6.1140 mL 15.2849 mL
10 mM 0.3057 mL 1.5285 mL 3.0570 mL 7.6425 mL
15 mM 0.2038 mL 1.0190 mL 2.0380 mL 5.0950 mL
20 mM 0.1528 mL 0.7642 mL 1.5285 mL 3.8212 mL
25 mM 0.1223 mL 0.6114 mL 1.2228 mL 3.0570 mL
30 mM 0.1019 mL 0.5095 mL 1.0190 mL 2.5475 mL
40 mM 0.0764 mL 0.3821 mL 0.7642 mL 1.9106 mL
50 mM 0.0611 mL 0.3057 mL 0.6114 mL 1.5285 mL
60 mM 0.0509 mL 0.2547 mL 0.5095 mL 1.2737 mL
80 mM 0.0382 mL 0.1911 mL 0.3821 mL 0.9553 mL
100 mM 0.0306 mL 0.1528 mL 0.3057 mL 0.7642 mL
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SARS-CoV-2-IN-13 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-1356961-10-5SARS-CoVSARS coronavirusSARS-CoV-2niclosamide analoguebioavailabilityhalf-lifeorallyInhibitorinhibitorinhibit

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