SARS-CoV-2-IN-13
Based on 1 Customer Validation
SARS-CoV-2-IN-13 (compound 5) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.057 μM. SARS-CoV-2-IN-13 is a niclosamide analogue. SARS-CoV-2-IN-13 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally.
For research use only. We do not sell to patients.
- Purity: 98.53%
- CAS No.: 56961-10-5
- Formula: C13H8Cl2N2O4
- Molecular Weight:327.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
15.1 μM
Compound: 10
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay
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[PMID: 32045239] |
| Vero C1008 | CC50 |
1.51 μM
Compound: 5
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Cytotoxicity against African Green monkey Vero E6 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against African Green monkey Vero E6 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 35344901] |
| Vero C1008 | CC50 |
64.2 μM
Compound: 5
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability preincubated for 2 hrs followed by SARS-CoV-2 addition measured after 24 hrs by CPE assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability preincubated for 2 hrs followed by SARS-CoV-2 addition measured after 24 hrs by CPE assay
|
[PMID: 35344901] |
Chemical Information
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CAS No. 56961-10-5
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Appearance Solid
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Molecular Weight 327.12
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Formula C13H8Cl2N2O4
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Color Light yellow to brown
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SMILES
O=C(C1=C(C=CC(Cl)=C1)O)NC2=CC(Cl)=C(C=C2)[N+]([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 125 mg/mL (382.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0570 mL | 15.2849 mL | 30.5698 mL | 76.4246 mL |
| 5 mM | 0.6114 mL | 3.0570 mL | 6.1140 mL | 15.2849 mL | |
| 10 mM | 0.3057 mL | 1.5285 mL | 3.0570 mL | 7.6425 mL | |
| 15 mM | 0.2038 mL | 1.0190 mL | 2.0380 mL | 5.0950 mL | |
| 20 mM | 0.1528 mL | 0.7642 mL | 1.5285 mL | 3.8212 mL | |
| 25 mM | 0.1223 mL | 0.6114 mL | 1.2228 mL | 3.0570 mL | |
| 30 mM | 0.1019 mL | 0.5095 mL | 1.0190 mL | 2.5475 mL | |
| 40 mM | 0.0764 mL | 0.3821 mL | 0.7642 mL | 1.9106 mL | |
| 50 mM | 0.0611 mL | 0.3057 mL | 0.6114 mL | 1.5285 mL | |
| 60 mM | 0.0509 mL | 0.2547 mL | 0.5095 mL | 1.2737 mL | |
| 80 mM | 0.0382 mL | 0.1911 mL | 0.3821 mL | 0.9553 mL | |
| 100 mM | 0.0306 mL | 0.1528 mL | 0.3057 mL | 0.7642 mL |
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