570-19-4
570-19-4
Chemical Structure
Europine
- CAS No.: 570-19-4
- Formula:C16H27NO6
- Molecular Weight:329.39
InChIKey: ZNEMYFCJOCCUJN-VFFTVRQLSA-N
SMILES: CO[C@@H](C)[C@](C(C)(O)C)(O)C(OCC1=CCN2[C@@]1([H])[C@@H](O)CC2)=O
Biological Activity: Europine is a pyrrolizidine alkaloid present in the whole plant of Heliotropium crassifolium. Europine dose-dependently increases the micronucleus rate of metabolically active HepaRG cells, while reducing the relative cell viability[1][2].
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Europine | Europine is a pyrrolizidine alkaloid present in the whole plant of Heliotropium crassifolium. Europine dose-dependently increases the micronucleus rate of metabolically active HepaRG cells, while reducing the relative cell viability. | |||||||||||||||||||||
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References
- [1]. Farsam H, et al. New pyrrolizidine alkaloids from Heliotropium crassifolium. Planta medica. 2000 May;66(4):389-91.
- [2]. Allemang A, et al. Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells. Food and Chemical Toxicology, 2018, 121: 72‑81.
