5854-93-3
5854-93-3
Chemical Structure
L-Alanosine
Synonym(s): NSC-153353; SDX-102
- CAS No.: 5854-93-3
- Formula:C3H7N3O4
- Molecular Weight:149.11
IUPAC Name: (S)-2-amino-3-(hydroxy(nitroso)amino)propanoic acid
InChIKey: MLFKVJCWGUZWNV-REOHCLBHSA-N
SMILES: N[C@@H](CN(O)N=O)C(O)=O
Biological Activity: L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine is the inhibitor for methylthioadenosine phosphorylase (MTAP)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L-Alanosine | 99.85% | L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine is the inhibitor for methylthioadenosine phosphorylase (MTAP). | ||||||||||||||||||||
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References
- [1]. Efferth T, et al. Identification of gene expression profiles predicting tumor cell response to L-alanosine. Biochem Pharmacol. 2003 Aug 15;66(4):613-21. [Content Brief]
- [2]. Chitnis MP, et al. Antitumor effect of L-alanosine (NSC 153553) on sensitive and resistant sublines of murine leukemias. Tumori. 1984 Aug 31;70(4):317-20. [Content Brief]
- [3]. Tyagi AK, et al. Identification of the antimetabolite of L-alanosine, L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide, in tumors and assessment of its inhibition of adenylosuccinate synthetase. Cancer Res. 1980 Dec;40(12):4390-7. [Content Brief]
