Antitumor effect of L-alanosine (NSC 153553) on sensitive and resistant sublines of murine leukemias

  • Tumori. 1984 Aug 31;70(4):317-20. doi: 10.1177/030089168407000404.
M P Chitnis ,  M K Adwankar ,  A J Amonkar
PMID: 6474581 DOI: 10.1177/030089168407000404
Abstract

The antitumor action of L-alanosine (NSC 153553) was investigated in murine leukemia P388 (P388/S), P388 resistant to adriamycin (P388/ADR), P388 resistant to vincristine (P388/VCR) and leukemia L5178Y sensitive to L-asparaginase (L5178Y/S). L-alanosine demonstrated good antineoplastic activity against P388/S and P388/ADR, whereas it showed better Anticancer activity against P388/VCR and L5178Y/S at the various dose levels employed.

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