585535-37-1
Chemical Structure
Azumamide E
- CAS. Nr.: 585535-37-1
- Formula:C27H38N4O6
- Molecular Weight:514.62
IUPAC Name: (Z)-6-((2R,5R,8R,11R,12S)-8-benzyl-2-isopropyl-5,12-dimethyl-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-11-yl)hex-4-enoic acid
InChIKey: DMXROUYLQHFRCS-GIORXHJXSA-N
SMILES: C([C@@H]1C(=O)N[C@H](C/C=C\CCC(O)=O)[C@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)N1)C2=CC=CC=C2
Biological Activity: Azumamide E is a HDAC inhibitor, with an IC50 of 0.064 μM against HDAC, 1.22 μM against HDAC1, and 2.28 μM against HDAC4. Azumamide E inhibits HDAC activity in nuclear extracts of leukemia cells and cervical adenocarcinoma cells. Azumamide E suppresses angiogenesis. Azumamide E is applicable for research on leukemia, cervical adenocarcinoma, and anti-angiogenesis[1][2].
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Azumamide E | Azumamide E is a HDAC inhibitor, with an IC50 of 0.064 μM against HDAC, 1.22 μM against HDAC1, and 2.28 μM against HDAC4. Azumamide E inhibits HDAC activity in nuclear extracts of leukemia cells and cervical adenocarcinoma cells. Azumamide E suppresses angiogenesis. Azumamide E is applicable for research on leukemia, cervical adenocarcinoma, and anti-angiogenesis. | |||||||||||||||||||||
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References
- [1]. Nakao Y, et al. Azumamides A-E: histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis. Angew Chem Int Ed Engl. 2006 Nov 20;45(45):7553-7. [Content Brief]
- [2]. Nakao Y, et al. Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 2008;18(9):2982-2984. [Content Brief]
