58602-66-7
Chemical Structure
Aminopterin sodium
Synonym(s): 4-Aminofolic acid sodium; APGA sodium
- CAS No.: 58602-66-7
- Formula:C19H18N8Na2O5
- Molecular Weight:484.38
IUPAC Name: sodium (4-(((2,4-diaminopteridin-6-yl)methyl)amino)benzoyl)-L-glutamate
InChIKey: USOUFAHHWNKDJC-LTCKWSDVSA-L
SMILES: O=C(O[Na])CC[C@@H](C(O[Na])=O)NC(C1=CC=C(NCC2=NC3=C(N)N=C(N)N=C3N=C2)C=C1)=O
Biological Activity: Aminopterin sodium (4-Aminofolic acid sodium) is an anti-tumor drug with immunosuppressive activity. Aminopterin sodium blocks the metabolism of folic acid by inhibiting the activity of dihydrofolate reductase, thereby affecting nucleic acid synthesis. Aminopterin sodium is mainly used to inhibit acute lymphoblastic leukemia and certain other types of cancer. Aminopterin sodium is also used clinically as an immunosuppressant to suppress autoimmune diseases[1].
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Aminopterin sodium | Aminopterin sodium (4-Aminofolic acid sodium) is an anti-tumor drug with immunosuppressive activity. Aminopterin sodium blocks the metabolism of folic acid by inhibiting the activity of dihydrofolate reductase, thereby affecting nucleic acid synthesis. Aminopterin sodium is mainly used to inhibit acute lymphoblastic leukemia and certain other types of cancer. Aminopterin sodium is also used clinically as an immunosuppressant to suppress autoimmune diseases. | |||||||||||||||||||||
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Keywords
