5896-59-3
Chemical Structure
Convolamine hydrochloride
- CAS No.: 5896-59-3
- Formula:C17H24ClNO4
- Molecular Weight:341.83
InChIKey: BGPGVBLFHMZCNG-MGMJSKNASA-N
SMILES: O=C(C(C=C1)=CC(OC)=C1OC)O[C@H](C[C@]2([H])CC3)C[C@]3([H])N2C.Cl
Biological Activity: Convolamine hydrochloride is a tropane alkaloid and a potent Sigma-1 receptor positive allosteric modulator with an IC50 value of 289 nM. Convolamine hydrochloride can be extracted from Convolvulus plauricalis. Convolamine hydrochloride exhibits cognitive-improving and neuroprotective properties. Convolamine hydrochloride can be used in research related to Wolfram syndrome and Alzheimer's disease[1][2].
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Convolamine hydrochloride | Convolamine hydrochloride is a tropane alkaloid and a potent Sigma-1 receptor positive allosteric modulator with an IC50 value of 289 nM. Convolamine hydrochloride can be extracted from Convolvulus plauricalis. Convolamine hydrochloride exhibits cognitive-improving and neuroprotective properties. Convolamine hydrochloride can be used in research related to Wolfram syndrome and Alzheimer's disease. | |||||||||||||||||||||
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- [1]. Crouzier L, et al. Convolamine, a tropane alkaloid extracted from Convolvulus plauricalis, is a potent sigma-1 receptor-positive modulator with cognitive and neuroprotective properties. Phytother Res. 2024;38(2):694-712. [Content Brief]
- [2]. Gapparov A M, et al. Alkaloids of Convolvulus subhirsutus from Uzbekistan[J]. Chemistry of Natural Compounds, 2007, 43(3): 291-292.
Keywords
