59708-49-5
59708-49-5
Chemical Structure
Orphine
- CAS No.: 59708-49-5
- Formula:C20H23N3O
- Molecular Weight:321.42
InChIKey: XUDUTRMKKYUAKI-UHFFFAOYSA-N
SMILES: O=C1NC2=C(N1C3CCN(C(C)C4=CC=CC=C4)CC3)C=CC=C2
Biological Activity: Orphine is an opioid compound. Orphine can enhance the antinociceptive effects in mice that are mitigated by Naloxone (HY-17417)[1][2].
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Orphine | Orphine is an opioid compound. Orphine can enhance the antinociceptive effects in mice that are mitigated by Naloxone (HY-17417). | |||||||||||||||||||||
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References
- [1]. Kennedy NM, et al. Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias. J Med Chem. 2018 Oct 11;61(19):8895-8907. [Content Brief]
- [2]. Vandeputte MM, et al. Elucidating the harm potential of brorphine analogues as new synthetic opioids: Synthesis, in vitro, and in vivo characterization. Neuropharmacology. 2024 Dec 1;260:110113. [Content Brief]
Keywords
