6008-93-1
Chemical Structure
Itaconoyl-CoA
Synonym(s): Itaconoyl coenzyme A
- CAS No.: 6008-93-1
- Formula:C26H40N7O19P3S
- Molecular Weight:879.62
IUPAC Name: 1-(4-methylisothiazol-5-yl)ethan-1-ol
InChIKey: NFVGYLGSSJPRKW-CITAKDKDSA-N
SMILES: O=C(CC(C(O)=O)=C)SCCNC(CCNC([C@H](O)C(C)(COP(O)(OP(O)(OC[C@@H]1[C@@H](OP(O)(O)=O)[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C32)O1)=O)=O)C)=O)=O
Biological Activity: Itaconoyl-CoA (Itaconoyl coenzyme A) is a coenzyme A derivative. Itaconoyl-CoA exhibits antibacterial and antiviral defense activities as well as the ability to regulate host immune metabolism. Itaconoyl-CoA acts as a multi-target modulator with a dual mechanism: in pathogens, it competitively inhibits isocitrate lyase (ICL) to block the glyoxylate shunt and inactivates MCM through itaconylation to disrupt branched-chain amino acid metabolism; in host cells, it activates the Nrf2 pathway to alleviate oxidative stress while inhibiting GSDMD oligomerization to block pyroptosis (pyroptosis). Itaconoyl-CoA can be used in research on infections, septicemia, and neurodegenerative diseases[1].
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Itaconoyl-CoA | Itaconoyl-CoA (Itaconoyl coenzyme A) is a coenzyme A derivative. Itaconoyl-CoA exhibits antibacterial and antiviral defense activities as well as the ability to regulate host immune metabolism. Itaconoyl-CoA acts as a multi-target modulator with a dual mechanism: in pathogens, it competitively inhibits isocitrate lyase (ICL) to block the glyoxylate shunt and inactivates MCM through itaconylation to disrupt branched-chain amino acid metabolism; in host cells, it activates the Nrf2 pathway to alleviate oxidative stress while inhibiting GSDMD oligomerization to block pyroptosis (pyroptosis). Itaconoyl-CoA can be used in research on infections, septicemia, and neurodegenerative diseases. | |||||||||||||||||||||
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