Itaconoyl-CoA
Itaconoyl-CoA (Itaconoyl coenzyme A) is a coenzyme A derivative. Itaconoyl-CoA exhibits antibacterial and antiviral defense activities as well as the ability to regulate host immune metabolism. Itaconoyl-CoA acts as a multi-target modulator with a dual mechanism: in pathogens, it competitively inhibits isocitrate lyase (ICL) to block the glyoxylate shunt and inactivates MCM through itaconylation to disrupt branched-chain amino acid metabolism; in host cells, it activates the Nrf2 pathway to alleviate oxidative stress while inhibiting GSDMD oligomerization to block pyroptosis (pyroptosis). Itaconoyl-CoA can be used in research on infections, septicemia, and neurodegenerative diseases.
For research use only. We do not sell to patients.
- CAS No.: 6008-93-1
- Formula: C26H40N7O19P3S
- Molecular Weight:879.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6008-93-1
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Molecular Weight 879.62
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Formula C26H40N7O19P3S
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SMILES
O=C(CC(C(O)=O)=C)SCCNC(CCNC([C@H](O)C(C)(COP(O)(OP(O)(OC[C@@H]1[C@@H](OP(O)(O)=O)[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C32)O1)=O)=O)C)=O)=O
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Synonyms
Itaconoyl coenzyme A
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Itaconoyl-CoA Related Classifications
HY-N10761 Related Classifications
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