61046-23-9
Chemical Structure
Epibestatin
- CAS No.: 61046-23-9
- Formula:C16H24N2O4
- Molecular Weight:308.37
InChIKey: VGGGPCQERPFHOB-HZSPNIEDSA-N
SMILES: CC(C[C@H](NC([C@H](O)[C@H](N)CC1=CC=CC=C1)=O)C(O)=O)C
Biological Activity: Epibestatin is an epimer of Bestatin (HY-B0134), a DPP4 inhibitor and protease inhibitor, with an IC50 of 17 μM against DPP4. As a stabilizer, Epibestatin binds to the cleft between 14-3-3 protein and plant proton pump PMA2, selectively stabilizing their interaction without affecting other 14-3-3 client proteins. Epibestatin triggers stomatal opening in leaf epidermis of Commelina communis. Epibestatin can be used in studies related to type 2 diabetes[1][2][3].
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Epibestatin | Epibestatin is an epimer of Bestatin (HY-B0134), a DPP4 inhibitor and protease inhibitor, with an IC50 of 17 μM against DPP4. As a stabilizer, Epibestatin binds to the cleft between 14-3-3 protein and plant proton pump PMA2, selectively stabilizing their interaction without affecting other 14-3-3 client proteins. Epibestatin triggers stomatal opening in leaf epidermis of Commelina communis. Epibestatin can be used in studies related to type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Kawaguchi M, et al. A time-resolved fluorescence probe for dipeptidyl peptidase 4 and its application in inhibitor screening. Chemistry (Weinheim an der Bergstrasse, Germany). 2010 Dec 03;16(45):13479-86. [Content Brief]
- [2]. Richter A, et al. A practical and convenient synthesis of the protease inhibitor epibestatin[J]. Synthesis, 2010, 2010(12): 2039-2042.
- [3]. Rose R, et al. Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions. Angew Chem Int Ed Engl. 2010 Jun 1;49(24):4129-32. [Content Brief]
