610787-07-0
Chemical Structure
E7974
- CAS No.: 610787-07-0
- Formula:C24H43N3O4
- Molecular Weight:437.63
IUPAC Name: (S,E)-4-((S)-2-((R)-1-isopropylpiperidine-2-carboxamido)-N,3,3-trimethylbutanamido)-2,5-dimethylhex-2-enoic acid
InChIKey: FWYMMXUDTATKLG-PGLMLKKXSA-N
SMILES: C(N[C@H](C(N([C@H](/C=C(/C(O)=O)\C)[C@@H](C)C)C)=O)C(C)(C)C)(=O)[C@@H]1N(C(C)C)CCCC1
Biological Activity: E7974 is a selective inhibitor of α-tubulin (α-tubulin) with an IC50 of 3.9 μM. E7974 disrupts mitotic spindle formation, induces G2-M phase cell cycle arrest, initiates apoptosis, activates caspase-3, and induces poly (ADP-ribose) polymerase cleavage. E7974 reduces the area of choroidal neovascularization in mouse models, and exerts anti-angiogenic effects when loaded in modified micelles. E7974 can be used in research related to cancer and choroidal neovascularization[1][2].
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E7974 | E7974 is a selective inhibitor of α-tubulin (α-tubulin) with an IC50 of 3.9 μM. E7974 disrupts mitotic spindle formation, induces G2-M phase cell cycle arrest, initiates apoptosis, activates caspase-3, and induces poly (ADP-ribose) polymerase cleavage. E7974 reduces the area of choroidal neovascularization in mouse models, and exerts anti-angiogenic effects when loaded in modified micelles. E7974 can be used in research related to cancer and choroidal neovascularization. | |||||||||||||||||||||
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- [1]. Kuznetsov G, et al. Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin. Mol Cancer Ther. 2009;8(10):2852-2860. [Content Brief]
- [2]. Takahashi K, et al. Anti-VEGFR2 Antibody-modified Micelle for Triggered Drug Delivery and Effective Therapy of Choroidal Neovascularization. Curr Neurovasc Res. 2019;16(3):258-265. [Content Brief]
Keywords
