613226-91-8
Chemical Structure
Synucleozid-2.0
- CAS No.: 613226-91-8
- Formula:C22H16BrN7OS
- Molecular Weight:506.38
InChIKey: LKEJPVTYVKHQNS-UHFFFAOYSA-N
SMILES: O=C(NC1=CC2=C(C=C1)C=NN2)CSC3=NN=C(N3C4=CC=C(C=C4)Br)C5=CC=NC=C5
Biological Activity: Synucleozid-2.0 is a blood-brain barrier-permeable inhibitor that binds to the IRE of SNCA mRNA, with a EC50 of 2.9 µM and a Kd value of 1.8 µM. Synucleozid-2.0 selectively binds to and stabilizes the A bulge and adjacent closed base pairs in the 5' UTR IRE of SNCA mRNA, blocks the translation process and reduces intracellular levels of α-synuclein. Synucleozid-2.0 exerts cytoprotective effects against cytotoxicity induced by α-synuclein preformed fibrils. Synucleozid-2.0 is applicable to the research of Parkinson's disease[1].
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Synucleozid-2.0 | 98.01% | Synucleozid-2.0 is a blood-brain barrier-permeable inhibitor that binds to the IRE of SNCA mRNA, with a EC50 of 2.9 µM and a Kd value of 1.8 µM. Synucleozid-2.0 selectively binds to and stabilizes the A bulge and adjacent closed base pairs in the 5' UTR IRE of SNCA mRNA, blocks the translation process and reduces intracellular levels of α-synuclein. Synucleozid-2.0 exerts cytoprotective effects against cytotoxicity induced by α-synuclein preformed fibrils. Synucleozid-2.0 is applicable to the research of Parkinson's disease. | ||||||||||||||||||||
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Keywords
