61325-80-2
Chemical Structure
Flumezapine
Synonym(s): LY 120363
- CAS No.: 61325-80-2
- Formula:C17H19FN4S
- Molecular Weight:330.42
IUPAC Name: 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine
InChIKey: JBHUBOISLBWHAR-UHFFFAOYSA-N
SMILES: FC1=CC2=C(NC3=C(C(N4CCN(CC4)C)=N2)C=C(C)S3)C=C1
Biological Activity: Flumezapine (LY 120363) is a potent and balanced antagonist of the dopamine D2 receptor and the 5-hydroxytryptamine receptor (5-HT receptor). Flumezapine does not alter the increase in serum cortisol caused by κ-opioid receptor agonists. Flumezapine inhibits the conditioned avoidance response in rats and has a low risk of extrapyramidal side effects. Flumezapine can be used in antipsychotic research[1][2].
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Flumezapine | Flumezapine (LY 120363) is a potent and balanced antagonist of the dopamine D2 receptor and the 5-hydroxytryptamine receptor (5-HT receptor). Flumezapine does not alter the increase in serum cortisol caused by κ-opioid receptor agonists. Flumezapine inhibits the conditioned avoidance response in rats and has a low risk of extrapyramidal side effects. Flumezapine can be used in antipsychotic research. | |||||||||||||||||||||
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Flumezapine-d8 hydrochloride | Flumezapine-d8 (LY 120363-d8) hydrochloride is deuterated labeled Flumezapine hydrochloride. Flumezapine hydrochloride is a potent and balanced antagonist of the dopamine D2 receptor and the 5-hydroxytryptamine receptor (5-HT receptor). Flumezapine hydrochloride does not alter the increase in serum cortisol caused by κ-opioid receptor agonists. Flumezapine hydrochloride inhibits the conditioned avoidance response in rats and has a low risk of extrapyramidal side effects. Flumezapine hydrochloride can be used in antipsychotic research. | |||||||||||||||||||||
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References
- [1]. Fuller RW, Mason NR. Flumezapine, an antagonist of central dopamine and serotonin receptors. Res Commun Chem Pathol Pharmacol. 1986 Oct;54(1):23-34. [Content Brief]
- [2]. Fuller RW, Snoddy HD. Flumezapine and zotepine: 5-hydroxytryptamine antagonism not involved in the lack of synergism of these antipsychotic drugs with amfonelic acid in rats. J Pharm Pharmacol. 1985 Oct;37(10):755-6. [Content Brief]
