61438-64-0
61438-64-0
Chemical Structure
Closantel sodium
- CAS No.: 61438-64-0
- Formula:C22H13Cl2I2N2NaO2
- Molecular Weight:685.06
IUPAC Name: sodium 2-((5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)carbamoyl)-4,6-diiodophenolate
InChIKey: LREGMDNUOGTSIK-UHFFFAOYSA-M
SMILES: O=C(NC1=CC(Cl)=C(C(C2=CC=C(Cl)C=C2)C#N)C=C1C)C3=CC(I)=CC(I)=C3O[Na]
Biological Activity: Closantel sodium is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel sodium is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel sodium inhibits the O. volvulus L3 to L4 molt of developing[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Closantel sodium | 99.69% | Closantel sodium is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel sodium is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel sodium inhibits the O. volvulus L3 to L4 molt of developing. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Closantel sodium (Standard) | ≥98% | Closantel (sodium) (Standard) is the analytical standard of Closantel (sodium). This product is intended for research and analytical applications. Closantel sodium is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel sodium is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel sodium inhibits the O. volvulus L3 to L4 molt of developing. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72. [Content Brief]
- [2]. G E Swan, et al. The pharmacology of halogenated salicylanilides and their anthelmintic use in animals. J S Afr Vet Assoc. 1999 Jun;70(2):61-70. [Content Brief]
