1. Anti-infection
  2. Parasite
  3. Closantel sodium

Closantel sodium 

Cat. No.: HY-17596A Purity: ≥98.0%
Handling Instructions

Closantel sodium is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel sodium is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel sodium inhibits the O. volvulus L3 to L4 molt of developing.

For research use only. We do not sell to patients.

Closantel sodium Chemical Structure

Closantel sodium Chemical Structure

CAS No. : 61438-64-0

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg USD 96 In-stock
Estimated Time of Arrival: December 31
500 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Closantel sodium is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel sodium is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel sodium inhibits the O. volvulus L3 to L4 molt of developing[1][2].

In Vitro

Closantel sodium, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

685.06

Formula

C₂₂H₁₃Cl₂I₂N₂NaO₂

CAS No.
SMILES

O=C(NC1=CC(Cl)=C(C(C2=CC=C(Cl)C=C2)C#N)C=C1C)C3=CC(I)=CC(I)=C3O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (182.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4597 mL 7.2986 mL 14.5973 mL
5 mM 0.2919 mL 1.4597 mL 2.9195 mL
10 mM 0.1460 mL 0.7299 mL 1.4597 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.04 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ClosantelParasitehalogenatedsalicylanilideOnchocercavolvuluschitinaseOvCHT1O. volvulusL3L4fromprotozoanschitotriosidaseInhibitorinhibitorinhibit

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Product Name:
Closantel sodium
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HY-17596A
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