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  2. Parasite
  3. Closantel

Closantel 

Cat. No.: HY-17596 Purity: >98.0%
Handling Instructions

Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.

For research use only. We do not sell to patients.

Closantel Chemical Structure

Closantel Chemical Structure

CAS No. : 57808-65-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg USD 96 In-stock
Estimated Time of Arrival: December 31
500 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing[1][2].

In Vitro

Closantel, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

663.07

Formula

C₂₂H₁₄Cl₂I₂N₂O₂

CAS No.

57808-65-8

SMILES

O=C(NC1=CC(Cl)=C(C(C2=CC=C(Cl)C=C2)C#N)C=C1C)C3=CC(I)=CC(I)=C3O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 49 mg/mL (73.90 mM)

H2O : 1 mg/mL (1.51 mM; ultrasonic and warming and heat to 80°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5081 mL 7.5407 mL 15.0814 mL
5 mM 0.3016 mL 1.5081 mL 3.0163 mL
10 mM 0.1508 mL 0.7541 mL 1.5081 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ClosantelParasitehalogenatedsalicylanilideOnchocercavolvuluschitinaseOvCHT1O. volvulusL3L4fromprotozoanschitotriosidaseInhibitorinhibitorinhibit

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Closantel
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HY-17596
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