2. Anti-infection
  3. Parasite
  4. Closantel

Closantel 

Cat. No.: HY-17596 Purity: ≥98.0%
COA Handling Instructions

Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.

For research use only. We do not sell to patients.

Closantel Chemical Structure

Closantel Chemical Structure

CAS No. : 57808-65-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 46 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 46 In-stock
Solid
50 mg USD 42 In-stock
100 mg USD 66 In-stock
200 mg USD 106 In-stock
500 mg USD 198 In-stock
1 g   Get quote  
5 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Closantel:

Closantel Related Antibodies

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing[1][2].

In Vitro

Closantel, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Closantel Related Antibodies
Molecular Weight

663.07

Appearance

Solid

Formula

C22H14Cl2I2N2O2
CAS No.
SMILES

O=C(NC1=CC(Cl)=C(C(C2=CC=C(Cl)C=C2)C#N)C=C1C)C3=CC(I)=CC(I)=C3O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 49 mg/mL (73.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5081 mL 7.5407 mL 15.0814 mL
5 mM 0.3016 mL 1.5081 mL 3.0163 mL
10 mM 0.1508 mL 0.7541 mL 1.5081 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.77 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Closantel Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Closantel57808-65-8ParasitehalogenatedsalicylanilideOnchocercavolvuluschitinaseOvCHT1O. volvulusL3L4fromprotozoanschitotriosidaseInhibitorinhibitorinhibit

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