616885-87-1
Chemical Structure
Memoquin
- CAS No.: 616885-87-1
- Formula:C38H56N4O4
- Molecular Weight:632.88
IUPAC Name: 2,5-bis((6-(ethyl(2-methoxybenzyl)amino)hexyl)amino)cyclohexa-2,5-diene-1,4-dione
InChIKey: VPXVPJQOPRBXPO-UHFFFAOYSA-N
SMILES: O=C1C(NCCCCCCN(CC2=CC=CC=C2OC)CC)=CC(C(NCCCCCCN(CC3=CC=CC=C3OC)CC)=C1)=O
Biological Activity: Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD)[1][2].
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Memoquin | Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD). | |||||||||||||||||||||
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- [1]. Capurro V, et al. Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer's disease. PLoS One. 2013;8(2):e56870. [Content Brief]
- [2]. Cavalli A, et al. A small molecule targeting the multifactorial nature of Alzheimer's disease. Angew Chem Int Ed Engl. 2007;46(20):3689-92. [Content Brief]
Keywords
