620940-01-4
Chemical Structure
AMPA receptor modulator-10
- CAS No.: 620940-01-4
- Formula:C19H20F3N3O
- Molecular Weight:363.38
InChIKey: PMXYSSZJPIWCHI-UHFFFAOYSA-N
SMILES: O=C(N1CCCC1)C2=CC=C(N3N=C(C(F)(F)F)C4=C3CCCC4)C=C2
Biological Activity: AMPA receptor modulator-10 (Compound 9a) is an orally active AMPA receptor (AMPAR) positive allosteric modulator. AMPA receptor modulator-10 exhibits potent activity (pEC50 = 5.0) on the GluA2 subtype of AMPAR, significantly enhancing glutamate-induced calcium influx and current responses. AMPA receptor modulator-10 can reverse the memory impairment induced by Scopolamine (HY-N0296) and enhance cognitive function. AMPA receptor modulator-10 can be used for the research of neurological disease, such as schizophrenia[1].
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AMPA receptor modulator-10 | 98.78% | AMPA receptor modulator-10 (Compound 9a) is an orally active AMPA receptor (AMPAR) positive allosteric modulator. AMPA receptor modulator-10 exhibits potent activity (pEC50 = 5.0) on the GluA2 subtype of AMPAR, significantly enhancing glutamate-induced calcium influx and current responses. AMPA receptor modulator-10 can reverse the memory impairment induced by Scopolamine (HY-N0296) and enhance cognitive function. AMPA receptor modulator-10 can be used for the research of neurological disease, such as schizophrenia. | ||||||||||||||||||||
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