62578-87-4
62578-87-4
Chemical Structure
MPO-IN-8
- CAS No.: 62578-87-4
- Formula:C12H9N3O2
- Molecular Weight:227.22
InChIKey: KGGKULXCFQNQPE-UHFFFAOYSA-N
SMILES: O=C1C2=C3C(C(N1N)=O)=CC(N)=CC3=CC=C2
Biological Activity:
MPO-IN-8 is an orally active myeloperoxidase (MPO) inhibitor. MPO-IN-8 can inhibit the generation of hypochlorous acid in neutrophils and the release of extracellular traps (NETosis). In mice with gouty arthritis, MPO-IN-8 can reduce swelling, lower peroxidase activity, and decrease IL-1β levels[1].
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MPO-IN-8 | MPO-IN-8 is an orally active myeloperoxidase (MPO) inhibitor. MPO-IN-8 can inhibit the generation of hypochlorous acid in neutrophils and the release of extracellular traps (NETosis). In mice with gouty arthritis, MPO-IN-8 can reduce swelling, lower peroxidase activity, and decrease IL-1β levels. |
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References
Keywords
