630122-37-1

AFG206 Chemical Structure
630122-37-1

Chemical Structure

AFG206

  • CAS No.: 630122-37-1
  • Formula:C20H19N3O2
  • Molecular Weight:333.38

IUPAC Name: 1-(4-ethylphenyl)-3-(4-(pyridin-4-yloxy)phenyl)urea

InChIKey: UUJSPHQATNSVLQ-UHFFFAOYSA-N

SMILES: O=C(NC1=CC=C(CC)C=C1)NC2=CC=C(C=C2)OC3=CC=NC=C3

Biological Activity: AFG206 is a first-generation ATP competitive “type II” FLT3 inhibitor. AFG206 potently inhibits cell proliferation (IC50 around 0.1 µM) via induction of Apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells. AFG206 is promising for research of acute myeloid leukemia[1].

Cat. No. Product Name Purity Description Pricing
HY-126920 		AFG206 AFG206 is a first-generation ATP competitive “type II” FLT3 inhibitor. AFG206 potently inhibits cell proliferation (IC50 around 0.1 µM) via induction of Apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells. AFG206 is promising for research of acute myeloid leukemia.
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