630122-37-1
630122-37-1
Chemical Structure
AFG206
- CAS No.: 630122-37-1
- Formula:C20H19N3O2
- Molecular Weight:333.38
IUPAC Name: 1-(4-ethylphenyl)-3-(4-(pyridin-4-yloxy)phenyl)urea
InChIKey: UUJSPHQATNSVLQ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(CC)C=C1)NC2=CC=C(C=C2)OC3=CC=NC=C3
Biological Activity: AFG206 is a first-generation ATP competitive “type II” FLT3 inhibitor. AFG206 potently inhibits cell proliferation (IC50 around 0.1 µM) via induction of Apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells. AFG206 is promising for research of acute myeloid leukemia[1].
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AFG206 | AFG206 is a first-generation ATP competitive “type II” FLT3 inhibitor. AFG206 potently inhibits cell proliferation (IC50 around 0.1 µM) via induction of Apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells. AFG206 is promising for research of acute myeloid leukemia. | |||||||||||||||||||||
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