640235-67-2
Chemical Structure
(S)-N-trans-feruloyloctopamine
- CAS No.: 640235-67-2
- Formula:C18H19NO5
- Molecular Weight:329.35
IUPAC Name: (S,E)-N-(2-hydroxy-2-(4-hydroxyphenyl)ethyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide
InChIKey: VJSCHQMOTSXAKB-UOWSJYKBSA-N
SMILES: C(=C/C(NC[C@@H](O)C1=CC=C(O)C=C1)=O)\C2=CC(OC)=C(O)C=C2
Biological Activity: (S)-N-trans-feruloyloctopamine is an isomer of N-trans-feruloyloctopamine (HY-N2232). N-trans-feruloyloctopamine is a natural hydroxycinnamic acid amide compound derived from garlic husk, possessing tyrosinase inhibitory, FGF2 inhibitory, anti-melanogenic, and anti-tumor activities, and is used in research related to hepatocellular carcinoma, pigmentation disorders, and UVB-induced skin damage[1][2][3][4].
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(S)-N-trans-feruloyloctopamine | (S)-N-trans-feruloyloctopamine is an isomer of N-trans-feruloyloctopamine (HY-N2232). N-trans-feruloyloctopamine is a natural hydroxycinnamic acid amide compound derived from garlic husk, possessing tyrosinase inhibitory, FGF2 inhibitory, anti-melanogenic, and anti-tumor activities, and is used in research related to hepatocellular carcinoma, pigmentation disorders, and UVB-induced skin damage. | |||||||||||||||||||||
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References
- [1]. Bai ZT, et al. Inhibition of invasion by N-trans-feruloyloctopamine via AKT, p38MAPK and EMT related signals in hepatocellular carcinoma cells. Bioorganic & medicinal chemistry letters. 2017 Feb 15;27(4):989-993. [Content Brief]
- [2]. Ma B, et al. N--Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis. Analytical cellular pathology (Amsterdam). 2021;2021:1560307. [Content Brief]
- [3]. Wu Y, et al. Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells. Bioorganic & medicinal chemistry letters. 2015 Apr 01;25(7):1476-8.
- [4]. Li B, et al. A Novel FGF2-Targeted Inhibitor (N-trans-feruloyloctopamine) Suppresses UVB-Induced Skin Damage and Hyperpigmentation. Advanced healthcare materials. 2026 Mar;15(9):e02250.
